Biocompare.com RSS feed http://www.biocompare.com/ © 2010 Biocompare.com Sun, 01 Aug 2010 02:01:48 GMT http://backend.userland.com/rss RSS.NET: http://www.rssdotnet.com/ Neuroscientists have long wondered how individual connections between brain cells remain diverse and "fit" enough for storing new memories. Reported in the prestigious science journal Neuron, a new study led by Dr. Inna Slutsky of the Sackler School of Medicine at Tel Aviv University describes what makes some memories stick. http://news.biocompare.com/newsstory.asp?id=335974 Biocompare.com Fri, 30 Jul 2010 13:53:00 GMT PITTSBURGH-Researchers at Carnegie Mellon University have developed a new fluorescent biosensor that could aid in the development of an important class of drugs that target a crucial class of proteins called G protein-coupled receptors (GPCRs). http://news.biocompare.com/newsstory.asp?id=335968 Biocompare.com Fri, 30 Jul 2010 13:42:00 GMT BOSTON -- The recent discovery of more than a thousand genes known as large intergenic non-coding RNAs (or "lincRNAs") opened up a new approach to understanding the function and organization of the genome. That surprising breakthrough is now made even more compelling with the finding that dozens of these lincRNAs are induced by p53 (the most commonly mutated gene in cancer), suggesting that this class of genes plays a critical role in cell development and regulation. Furthermore, the researchers identify one lincRNA in particular (lincRNA-p21), and demonstrate its critical role in suppressing the reading of many genes across the genome following p53 activation. Led by investigators at Beth Israel Deaconess Medical Center (BIDMC) and the Broad Institute, the results are published in the August 6 issue of the journal Cell, which appears on-line today. http://news.biocompare.com/newsstory.asp?id=335957 Biocompare.com Fri, 30 Jul 2010 13:03:00 GMT Aggressive blood sugar control does not improve survival in diabetic patients with kidney failure, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN). The results suggest that physicians should individualize blood sugar targets for these patients and not rely on recommendations based on studies in the general population. http://news.biocompare.com/newsstory.asp?id=335952 Biocompare.com Fri, 30 Jul 2010 12:19:00 GMT Researchers in Heidelberg and Stanford have discovered a new signalling pathway of brain cells that explains how widely used antihypertensive drugs could keep inflammation in multiple sclerosis (MS) in check. The peptide angiotensin not only raises blood pressure but also activates the immunological messenger substance TGF beta on a previously unknown communication pathway in the brain. http://news.biocompare.com/newsstory.asp?id=335767 Biocompare.com Thu, 29 Jul 2010 15:32:00 GMT Researchers hoping to simplify their gene expression studies can now watch an instructional video by Bio-Rad that shows best practices from pre-transfection cell counting with an automated cell counter to the analysis of gene expression using real-time PCR. The video, entitled "Using an Automated Cell Counter to Simplify Gene Expression Studies: siRNA Knockdown of IL-4 Dependent Gene Expression in Namalwa Cells," is available at http://bit.ly/a3Wroj. http://news.biocompare.com/newsstory.asp?id=335740 Biocompare.com Thu, 29 Jul 2010 08:23:00 GMT Intercept Pharmaceuticals, Inc., a clinical stage biopharmaceutical company developing novel therapeutics for chronic fibrotic and metabolic diseases, today announced the signing of a cooperative research and development agreement (CRADA) with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health to conduct a double blind, multi-center, study to evaluate the effects of obeticholic acid in patients with nonalcoholic steatohepatitis (NASH). Obeticholic acid is the generic name for INT-747, Intercept's first-in-class FXR agonist. http://news.biocompare.com/newsstory.asp?id=335607 Biocompare.com Thu, 29 Jul 2010 05:33:00 GMT Women with higher risk scores that consisted of having certain genetic variants most strongly linked to breast cancer had an associated higher risk of breast cancer, with these scores also highly predictive of estrogen receptor-positive disease, according to a study in the July 28 issue of JAMA. http://news.biocompare.com/newsstory.asp?id=335538 Biocompare.com Wed, 28 Jul 2010 12:10:00 GMT The latest Perspectives in General Physiology series introduces the newest technologies in the field of calcium signaling, which plays a central role in many cellular processes. The Perspectives appear in the August issue of the Journal of General Physiology (www.jgp.org). http://news.biocompare.com/newsstory.asp?id=335324 Biocompare.com Tue, 27 Jul 2010 12:02:00 GMT Global Cell Solutions (GCS) has received a National Science Foundation (NSF) Small Business Innovation Research (SBIR) grant to study the immobilization of growth factors on the GCS GEM substrate. The NSF SBIR program supports the development of new technologies through funding provided to high-quality opportunities that could lead to significant commercial and public benefit. http://news.biocompare.com/newsstory.asp?id=335314 Biocompare.com Tue, 27 Jul 2010 10:31:00 GMT